Cimetidine is an H2 – anti histaminic drug that has been widely used in the treatment of gastric ulcers. It is suitable drug for gastro-retentive floating tablets due to its short half life and poor absorption in lower gastro intestinal tract. In the present research work Box – Behnken Design was used for optimization of level of independent variables (sodium bicarbonate, bees’ wax and ethyl cellulose) on dependent variables (floating lag time and percent release at the end of 24 hrs) in the formulation of Cimetidine gastro retentive floating tablets with less experimentation. Based on the polynomial equations and from the results it was concluded that sodium bicarbonate (10%), bees’ wax (10%) and ethyl cellulose (15%) were favourable for formulation of gastro – retentive floating tablets employing HPMC K4 as release retardant.
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